Patients with Attention-Deficit/Hyperactivity Disorder (ADHD) and obsessive/compulsive disorder (OCD) share problems with sustained attention, and are proposed to share deficits in switching between default mode and task positive promotional-material networks.The aim of this study was to investigate shared and disorder-specific brain activation abn
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells
Abstract The excessive cytokine release and limited persistence represent major Gift Items challenges for chimeric antigen receptor T (CAR-T) cell therapy in diverse tumors.Conventional CARs employ an intracellular domain (ICD) from the ? subunit of CD3 as a signaling module, and it is largely unknown how alternative CD3 chains potentially contribu
Taking lead from the community: What do young people living with HIV want us to research?
Priority setting workshops enable researchers to take the lead from people with relevant lived experience, and design research which authentically responds to community needs.Large-scale global priority setting exercises have previously identified key research questions related to paediatric and adolescent HIV treatment, prevention, and Vehicle Par
Conducting a conventional multi-casualty incident in COVID-19 personal protective equipment - a semi-structured interview
Abstract Background The risk of COVID-19 transmission to healthcare professionals is likely to continue for the foreseeable future.The wearing of personal protective equipment (PPE) presents a number of potential challenges to responders that may impact upon the management of patients in a multi-casualty incident.This report describes a multi-agenc